SC/How Pig Guts Became the Next Bright Hope for Regenerating Human Limbs

Corporal Isais Hernandez shows off his healing 

thigh muscles, credit photography : Scott Lewis

A remarkable substance extracted from pigs enables the body to regenerate lost muscle tissue, including fingertips and big chunks of muscle. And that may not be all it can do...

The strange sensation in his right thigh muscle began as a faint pulse. slowly, surely, it was becoming more pronounced. Some people would have thought it impossible. But Corporal Isaias Hernandez could feel his quadriceps getting stronger. The muscle was growing back.

When he first arrived in the trauma unit of San Antonio’s Brooke Army Medical Center in December 2004, Hernandez’s leg looked to him like something from KFC. “You know, like when you take a bite out of the drumstick down to the bone?” Hernandez recalls. The 19-year-old Marine, deployed in Iraq, had been trying to outfit his convoy truck with a makeshift entertainment system for a long road trip when the bomb exploded. The 12-inch TV he was clutching to his chest shielded his vital organs; his buddy carrying the DVDs wasn’t so lucky. 

Generally people never recovered from wounds like his. Flying debris had ripped off nearly 70 percent of Hernandez’s right thigh muscle, and he had lost half his leg strength. Remove enough of any muscle and you might as well lose the whole limb, the chances of regeneration are so remote. The body kicks into survival mode, pastes the wound over with scar tissue, and leaves you to limp along for life.

For Hernandez, it had been three years and there was no mistaking it: He had hit a plateau. Lately the talk of amputation had cropped up again. The pain was constant, and he was losing hope. Then his life took another radical turn. He saw a science documentary on the Discovery Channel (no relation to this magazine) that told the story of a war veteran in Cincinnati named Lee Spievack whose fingertip had been severed by the propeller of a model airplane. Spievack’s brother, a surgeon in Boston, had sent him a vial of magic powder—the narrator called it “pixie dust”—and told him to sprinkle it onto the wound. Lee was to cover his hand with a plastic bag and reapply the powder every other day until his supply ran out. After four months, Lee’s fingertip had regenerated itself, nail, bone, and all...