Showing posts with label smoking addiction. Show all posts
Showing posts with label smoking addiction. Show all posts

16 Nov 2011

Smokeout Day: The Best Ways to Quit

As thousands of smokers across the United States try to kick their bad habit as part of the Great American Smokeout on Thursday, experts agree that a two-pronged strategy is the best bet for success.

"The U.S. Public Health Service has twice done very extensive reviews of all the evidence, and [best] is a combination of counseling/advice, by pharmacists, physicians or quitlines, plus medicine," said Thomas Glynn, director of cancer science and trends and of international cancer control for the American Cancer Society.
A lot has changed since 1976, when the first smokeout took place, Glynn noted. "People could smoke on airplanes and in restaurants; the person sitting next to you in the movie theater could be smoking. Two of every five people smoked; now it's one of five."

Another difference: "Now, there are a number of ways that people can succeed, [including] seven medications approved by the FDA [U.S. Food and Drug Administration]," he said.
Still, many Americans resist medications or counseling, and rely on personal willpower to get them through nicotine withdrawal.
"Cold turkey, sheer willpower; the best data is that about 5 percent of people succeed," said Dr. Norman Edelman, chief medical officer at the American Lung Association.
"People who smoke 10 cigarettes a day, light smokers, if they want to try quitting on their own, that's fine," said Gary Giovino, chair of the department of community health and health behavior at the University at Buffalo, State University of New York. For heavy smokers, he recommends starting with nicotine replacement therapy.

Smoking-cessation medications come "in three buckets: nicotine replacement, Wellbutrin/Zyban (bupropion) and Chantix (varenicline)," said Dr. Nancy Rigotti, director of the tobacco research and treatment unit at Massachusetts General Hospital in Boston. "They all work. It's better to take one than none."
Nicotine patches give users a steady dose of nicotine through the skin and come in 16- or 24-hour varieties, by prescription or over-the-counter. Fast-acting forms of nicotine replacement therapy are lozenges and gum, available over-the-counter, and prescription inhalers and nasal sprays.
"You use the patch to get constant coverage and use the other forms to get over cravings, as supplements," Rigotti said.

In its 2008 recommendations, the U.S. Agency for Healthcare Research and Quality advised clinicians to consider nicotine patches in combination with Wellbutrin or Zyban for smokers unable to quit with a single type of medication. Wellbutrin, Zyban and Chantix all carry black box warnings about the increased possibility of suicidal thoughts, although Chantix has come under the most scrutiny for this potential side effect.
"The fear is of big changes in behavior," Giovino said. "The question is, does it happen more often with Chantix or if you stop smoking with a nicotine replacement drug?"

"If people want something based on a prescription, they should discuss it with their doctor," Giovino said.
Telephone quitlines can be effective, convenient and free, but are underused because smokers have misconceptions about them, Rigotti and Giovino said.
"It's like getting a phone appointment with your doctor," Rigotti said. "They'll schedule calls around your quit day. It's so you can talk to somebody who can help you if you've slipped, you can get back on the wagon. It's practical information, not psychotherapy, not voodoo."

Internet quit sites provide another option. For instance, the American Lung Association offers the "Freedom From Smoking" online program, Edelman noted.
Even with outside help, willpower still comes into play in breaking long-held habits and battling sharp cravings.
Giovino suggested the "'six Ds': delay, drink water, distract yourself, discuss with someone, deep breath and, finally, don't debate. People who do best are those who decide smoking is no longer an option."
(HealthDay News)
»»  read more

10 Aug 2011

Why heavy smokers feel sad after quitting?

Heavy smokers may experience sadness after quitting because early withdrawal leads to an increase in the mood-related brain protein monoamine oxidase A (MAO-A), a new study by the Centre for Addiction and Mental Health (CAMH) has shown. This finding, which was published in the Archives of General Psychiatry, may also explain why heavy smokers are at high risk for clinical depression.
Using an advanced brain imaging method, a team led by Senior Scientist Dr. Jeffrey Meyer discovered that MAO-A levels in the brain regions that control mood rose by 25 per cent eight hours after withdrawal from heavy cigarette smoking. These levels were much higher than in a comparison group of non-smoking study participants. All 48 participants filled out questionnaires, and smokers with high brain MAO-A levels during withdrawal also reported greater feelings of sadness.
“Understanding sadness during cigarette withdrawal is important because this sad mood makes it hard for people to quit, especially in the first few days. Also, heavy cigarette smoking is strongly associated with clinical depression,” said Dr. Meyer, who holds a Canada Research Chair in the Neurochemistry of Major Depression. “This is the first time MAO-A, a brain protein known to be elevated in clinical depression has been studied during cigarette withdrawal.”

MAO-A “eats up” chemicals in the brain, such as serotonin, that help maintain a normal mood. When MAO-A levels are higher as in early cigarette withdrawal, it means that this removal process is overly active, making people feel sad. For this study, MAO-A was detected using a brain imaging technique called positron emission tomography (PET). CAMH has the only PET scanner in the world dedicated solely to mental health and addiction research.
A specific substance in cigarette smoke, called harman, may be responsible for these changes, the researchers note. During active smoking, harman attaches to MAO-A. During early withdrawal in heavy smokers who had 25 or more cigarettes a day, MAO-A levels rose rapidly to a level beyond that seen in the healthy comparison group.
“This study opens new ways to prevent sad mood during cigarette withdrawal to make it easier to quit smoking. For example, it may be possible to improve the existing cigarette filters that partially screen out harman, or regulate the amount of tryptophan contained in cigarettes, since tryptophan becomes harman when it burns,” said Dr. Meyer, who is also head of the Neurochemical Imaging Program in Mood Disorders at CAMH’s Research Imaging Centre, and professor of psychiatry at the University of Toronto. “We also identified MAO-A as a target to shut down during the early critical stage of withdrawal with a short course of medication, but this requires further study.”
“This finding may explain why heavy smokers are at high risk for clinical depression,” says Dr. Anthony Phillips, Scientific Director of the Canadian Institutes of Health Research’s (CIHR’s) Institute of Neurosciences, Mental Health and Addiction, which funded this study.
»»  read more
Related Posts .